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Paeoniflorin regulates macrophage polarization and protects the intestinal barrier through SOCS1/JAK1/STAT1 pathway in ulcerative colitis
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DOI：10.1016/j.intimp.2026.117008.png)
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Abstract
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• Paeoniflorin protects intestinal barrier integrity. • Paeoniflorin delays and inhibits macrophages to polarize to M1 in ulcerative colitis. • Paeoniflorin inhibits the phosphorylation of the JAK1/STAT1 pathway and upregulates the negative feedback regulatory factor SOCS1.
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