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Paeonol ameliorates scopolamine- and β-amyloid 1–42 oligomer-induced cognitive impairments through modulation of the TGR5–PKA–cAMP response element-binding–brain-derived neurotrophic factor pathway and inhibition of acetylcholinesterase
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DOI：10.1016/j.neuint.2026.106188.png)
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Abstract
En 中文
• Paeonol improves cognitive deficits in scopolamine and Aβ1–42 mouse models. • Paeonol activates the TGR5–PKA–CREB–BDNF signaling pathway in the brain. • Molecular docking identifies TGR5 as a potential binding target of paeonol. • Paeonol suppresses acetylcholinesterase activity comparable to donepezil.
Keywords:
Paeonol
cognitive impairment
TGR5
PKA
CREB
BDNF
acetylcholinesterase
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