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Pallidal circuits drive addiction behavior
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DOI：10.1016/j.tins.2023.10.001.png)
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摘要
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Understanding the neural mechanisms that control addiction processes, including drug-seeking and relapse, is key to finding new targets for substance use dis-order (SUD) pharmacotherapies and circuit-based therapies. Addictive drugs alter activity in distinct neural circuits that can lead to SUD symptoms, including compulsive drug craving and taking. This includes the pallidum, a region in the basal ganglia that acts as an integrator of associative, sensorimotor, and limbic information to shape motor responses, promote reward-learning, and regulate habit formation. Here, we review key findings that demonstrate the sub-regional and circuit-specific functions of the pallidum that drive addiction-related behaviors in rodents. We also highlight newly discovered mechanisms within distinct cell types and circuits of the pallidum that drive drug-seeking. Overall, this review serves to emphasize the importance of the pallidum in addiction processes and underscore the need for studying circuit-specific mechanisms in SUD research.
Keyword:
VENTRAL TEGMENTAL AREA
GLOBUS-PALLIDUS
BASAL GANGLIA
ENTOPEDUNCULAR NUCLEUS
PROJECTION NEURONS
OPIOID MODULATION
DRUG-ADDICTION
REWARD
PATHWAYS
ROLES
期刊
IF:
15.1
论文数:
5.3K
被引数:
2.2W
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