Paracetamol micro-structure analysis by optical mapping

Reo Honda

doi:10.1016/j.apsusc.2018.12.121

2019-04-01

DOI：10.1016/j.apsusc.2018.12.121

原文链接

查看原文

摘要

En 中文

Domain structure of paracetamol - popular antipyretic analgesic - was investigated by infrared (IR) spectroscopy using synchrotron radiation. Absorbance and retardance maps reveal molecular orientation inside the micro-domains of the paracetamol form II which has a better water solubility and compressibility compared to the commercially used forms I. The developed method of analysis representing orientation of optical slow(fast)- axis is compared with azimuthal orientation of the absorbance at several specific IR bands using vector maps. High brightness of synchrotron radiation and hyper-spectral mapping of structural domains in paracetamol clearly reveals the domain boundaries and can potentially be used to observe in situ intra-phase transformations of paracetamol forms-I, II, III and melting, which are important for making medical tablets and powders by an industrial process.

Keyword:

Orientational anisotropy

Absorbance

Retardance

Paracetamol

Water solubility

AI总结

对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

Applied Surface Science

IF:

6.9

论文数:

6.2W

被引数:

19.4W

机构

Institute of Science Tokyo

学者数:

3.2W

论文数: 2.7W

被引数: 117

Tokyo Institute of Technology

学者数:

1.1W

论文数: 9.0K

被引数: 1.9W

Swinburne University of Technology

学者数:

9.3K

论文数: 1.2W

被引数: 2.0W

查看更多机构

引用论文

THE BRAIN BARRIER SYSTEM—V STEREOSPECIFICITY OF AMINO ACID UPTAKE, EXCHANGE AND EFFLUX

Journal of Neurochemistry

IF0

2006-12-12

PREAI

A. Lajtha; J. Toth

Nanostructured Antireflective and Thermoisolative Cicada Wings

LANGMUIR

IF3.9

2016-04-29

PREAI

Morikawa, Junko; Ryu, Meguya; Seniutinas, Gediminas; Balcytis, Armandas; Maximova, Ksenia; Wang, Xuewen; Zamengo, Massimiliano; Ivanova, Elena P.; Juodkazis, Saulius

FT-IR Image Processing Algorithms for In-Plane Orientation Function and Azimuth Angle of Uniaxially Drawn Polyethylene Composite Film

MACROMOLECULES

IF5.2

2011-04-29

PREAI

Hikima, Yuta; Morikawa, Junko; Hashimoto, Toshimasa

Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules

NATURE COMMUNICATIONS

IF15.7

2015-06-04

1.2K

OAAI

Liang, Kang; Ricco, Raffaele; Doherty, Cara M.; Styles, Mark J.; Bell, Stephen; Kirby, Nigel; Mudie, Stephen; Haylock, David; Hill, Anita J.; Doonan, Christian J.; Falcaro, Paolo

Thermal analysis of paracetamol polymorphs by FT-IR spectroscopies

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

IF3.1

2011-01-01

PREAI

Zimmermann, Boris; Baranovic, Goran

Hydrogenation homogene catalysee par les composes de coordination des platinoides

Journal of Organometallic Chemistry

IF0

1978-11-01

PREAI

R. Bonnaire; L. Horner; F. Schumacher

Orientational Mapping Augmented Sub-Wavelength Hyper-Spectral Imaging of Silk

SCIENTIFIC REPORTS

IF3.9

2017-08-07

OAAI

Ryu, Meguya; Balcytis, Armandas; Wang, Xuewen; Vongsvivut, Jitraporn; Hikima, Yuta; Li, Jingliang; Tobin, Mark J.; Juodkazis, Saulius; Morikawa, Junko

Effectiveness of senna vs polyethylene glycol as laxative therapy in children with constipation related to anorectal malformation

Journal of Pediatric Surgery

IF0

2017-01-01

PREAI

Karla Alejandra Santos-Jasso; José Luis Arredondo-García; Jorge Maza-Vallejos; Pablo Lezama-Del Valle

Application of femtosecond laser pulses for microfabrication of transparent media 飞秒激光脉冲在透明介质微细加工中的应用

APPLIED SURFACE SCIENCE

IF6.9

2002-09-01

PREAI

Juodkazis, S; Matsuo, S; Misawa, H; Mizeikis, V; Marcinkevicius, A; Sun, HB; Tokuda, Y; Takahashi, M; Yoko, T; Nishii, J