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Parent-of-origin effects in Alzheimer’s liability dissociate neurocognitive and cardiovascular traits in at-risk individuals
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DOI：10.1016/j.xcrm.2026.102943.png)
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Abstract
En 中文
• Genetically anchored parent-of-origin subgroups coexist in Alzheimer’s disease • Three multimodal intermediate phenotypes delineate distinct gender-biased profiles • Lineage biases in vulnerable brain structures emerge in at-risk individuals
Keywords:
lineage
phenomics
PREVENT-AD
Alzheimer’s disease
family risk
parent-of-origin effects
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