.png){kind=icon}
返回
Patch-seq: Advances and Biological Applications
.png){kind=icon}
PRE
AI
DOI：10.1007/s10571-023-01436-3.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Multimodal analysis of gene-expression patterns, electrophysiological properties, and morphological phenotypes at the single-cell/single-nucleus level has been arduous because of the diversity and complexity of neurons. The emergence of Patch-sequencing (Patch-seq) directly links transcriptomics, morphology, and electrophysiology, taking neuroscience research to a multimodal era. In this review, we summarized the development of Patch-seq and recent applications in the cortex, hippocampus, and other nervous systems. Through generating multimodal cell type atlases, targeting specific cell populations, and correlating transcriptomic data with phenotypic information, Patch-seq has provided new insight into outstanding questions in neuroscience. We highlight the challenges and opportunities of Patch-seq in neuroscience and hope to shed new light on future neuroscience research.
Keyword:
Patch-clamp
Sc/snRNA-seq
Patch-seq
Electrophysiology
Transcriptomics
Morphology
Multimodal
期刊
IF:
4.8
论文数:
3.4K
被引数:
7.3K
机构
引用论文
THYROID-STIMULATING HORMONE MEASUREMENTS BY IMMUNORADIOMETRIC ASSAY IN SEVERELY ILL PATIENTS.png)
The Lancet
The LancetIF0
PREAI
分享收藏Task constraints modulate activation in right ventral lateral prefrontal cortex任务约束调节右腹外侧前额叶皮层的激活NeuroImage
NeuroImageIF0
PREAI
分享收藏In Vivo Whole-Cell Patch-Clamp Methods: Recent Technical Progress and Future Perspectives体内全细胞膜片钳方法: 最新技术进展和未来展望SENSORS
OAAI
SENSORSIF3.5
OAAI分享收藏PURIFIED ANTIGEN RADIOIMMUNOASSAY IN SEROLOGICAL DIAGNOSIS OF SCHISTOSOMIASIS MANSONIThe Lancet
The LancetIF0
PREAI
分享收藏
查看更多内容