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Pathway Optimization for Effective Heterologous Synthesis of Ergothioneine in Aspergillus niger
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DOI：10.1016/j.jbiotec.2026.04.018.png)
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Abstract
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• Achieved the first heterologous synthesis of ergothioneine (EGT) in Aspergillus niger. • Identified Tr egt1 and Nc egt2 as the optimal genes enhancing EGT biosynthesis. • Precursor supplementation and fermentation optimization boosted EGT yield to 3.12 g/L. • Established A. niger as a promising fungal chassis for eukaryotic metabolic engineering.
Keywords:
ergothioneine
Aspergillus niger
heterologous synthesis
metabolic engineering
pathway optimization
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3.9
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1.5W
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