Pattern separation in the hippocampus

doi:10.1016/j.tins.2011.06.006

2011-10-01

1.2K

Michael A. Yassa *

Craig E.L. Stark

DOI：10.1016/j.tins.2011.06.006

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摘要

En 中文

The ability to discriminate among similar experiences is a crucial feature of episodic memory. This ability has long been hypothesized to require the hippocampus, and computational models suggest that it is dependent on pattern separation. However, empirical data for the role of the hippocampus in pattern separation have not been available until recently. This review summarizes data from electrophysiological recordings, lesion studies, immediate-early gene imaging, transgenic mouse models, as well as human functional neuroimaging, that provide convergent evidence for the involvement of particular hippocampal subfields in this key process. We discuss the impact of aging and adult neurogenesis on pattern separation, and also highlight several challenges to linking across species and approaches, and suggest future directions for investigation.

Keyword:

COMPLEMENTARY-LEARNING-SYSTEMS

MEDIAL TEMPORAL-LOBE

CIRCUIT-SPECIFIC ALTERATIONS

CA3 NMDA RECEPTORS

DENTATE GYRUS

RECOGNITION MEMORY

PERIRHINAL CORTEX

OBJECT RECOGNITION

ADULT NEUROGENESIS

GRANULE CELLS

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期刊

Trends in Neurosciences

IF:

15.1

论文数:

5.3K

被引数:

2.2W

机构

Johns Hopkins University

学者数:

10.2W

论文数: 8.8W

被引数: 13.0W

University of California System

学者数:

37.5W

论文数: 33.7W

被引数: 6.6K

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