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Patterned and Gradient Conductive Hydrogel for Regulating Nerve Cell Behavior
DOI:10.1021/acs.biomac.5c01631.png)
摘要
En 中文
构建兼具梯度导电性与图案化形貌的多功能水凝胶支架,以模拟细胞外基质并调控神经元行为仍具挑战性。本研究采用电泳策略开发了一种导电性、形貌梯度的水凝胶。以热敏性聚异氰酸肽(PIC)水凝胶为基质,氧化石墨烯纳米片(GO)在电场作用下迁移,形成连续梯度。该梯度实现了空间变化的导电性、微观结构和纤维取向。通过调节场强和电极配置,可精确控制GO分布及图案化形貌。SH-SY5Y细胞沿梯度方向对齐,高GO区域较低GO区域与对照组更能促进细胞圆形化并减小细胞面积。本研究为设计可编程多梯度导电水凝胶提供了新见解,在推进神经组织工程领域具有巨大潜力。
Keyword:
Electrical conductivity
Electrodes
Hydrogels
Morphology
Scaffolds
期刊
IF:
5.4
论文数:
1.2W
被引数:
4.1W
机构
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