Patterned wireless transcranial optogenetics generates artificial perception

doi:10.1038/s41593-025-02127-6

2025-12-08

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Abraham Vázquez‐Guardado *

Yonggang Huang (Yonggang Huang) *

Yevgenia Kozorovitskiy *

John A. Rogers *

DOI：10.1038/s41593-025-02127-6

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摘要

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合成与典型感觉通道无关的可感知人工神经输入，仍然是开发下一代脑−机接口的基础性挑战。建立具有长期稳定性、微创、无线有效且小型化的平台，对于创建能够调节人工感知反馈的研究方法和具有临床意义且有效的生物界面至关重要。本研究展示了一种小型化、完全植入式经颅光遗传神经刺激器，该装置旨在通过无线实时模式化大规模皮质群集来生成人工感知。实验验证的数值模拟表征了光和热的传播，而神经元响应则通过在体电生理学和分子方法进行评估。操作性学习期间的提示辨别实验证明了无线生成小鼠感知的人工感知，其中跨大规模皮质网络的空间距离和基于顺序分析的辨别预测了性能。这些概念和技术上的进步扩展了对人工模式化神经活动的理解及其被大脑感知的认识，以指导下一代全光学脑−机通信的演变。这项工作介绍了一种完全植入式无线光遗传设备，该设备可通过颅骨递送时空模式化的皮质刺激，并在小鼠中产生人工感知。

Keyword:

optogenetics

wireless stimulation

artificial perception

brain-machine interface

cortical ensembles

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Nature Neuroscience

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640

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shanghai jiao tong university

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