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Peptide array functionalization via the Ugi four-component reaction
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DOI：10.1039/c7cc01945a.png)
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摘要
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The Ugi four-component reaction was investigated as a tool for the functionalization of peptide arrays via post-synthetic side-chain modification, mimicking post-translational processes. Additionally, as a proof of concept for the synthesis of peptidomimetics on arrays, the integration of an Ugi unit into a growing peptide chain was demonstrated.
Keyword:
MULTICOMPONENT REACTIONS
COMBINATORIAL SYNTHESIS
SOLID-PHASE
CYCLIC-PEPTIDES
SIDE-CHAINS
AMINO
CONDENSATION
PEPTIDOMIMETICS
ISOCYANIDES
MACROARRAYS
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IF:
4.2
论文数:
5.9W
被引数:
16.5W
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