.png){kind=icon}
返回
Peptide-based delivery to bone
.png){kind=icon}
PRE
AI
DOI：10.1016/j.addr.2012.05.017.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Peptides are attractive as novel therapeutic reagents, since they are flexible in adopting and mimicking the local structural features of proteins. Versatile capabilities to perform organic synthetic manipulations are another unique feature of peptides compared to protein-based medicines, such as antibodies. On the other hand, a disadvantage of using a peptide for a therapeutic purpose is its low stability and/or high level of aggregation. During the past two decades, numerous peptides were developed for the treatment of bone diseases, and some peptides have already been used for local applications to repair bone defects in the clinic. However, very few peptides have the ability to form bone themselves. We herein summarize the effects of the therapeutic peptides on bone loss and/or local bone defects, including the results from basic studies. We also herein describe some possible methods for overcoming the obstacles associated with using therapeutic peptide candidates. (C) 2012 Elsevier B.V. All rights reserved.
Keyword:
RANKL (receptor activator of NF-kappa B ligand)
Antagonist
Bone resorption inhibitory peptide
Bone formation stimulatory peptide
Cholesterol-bearing pullulan (CHP) nanogel
BMP
Collagen
Thrombin
Bone-targeting peptide
Half-life
Stability
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
17.6
论文数:
4.5K
被引数:
5.1W
机构
引用论文
Calcitonin-gene-related peptide stimulates stromal cell osteogenic differentiation and inhibits RANKL induced NF-κB activation, osteoclastogenesis and bone resorption降钙素基因相关肽刺激基质细胞成骨分化并抑制RANKL诱导的nf-κb活化、破骨细胞生成和骨吸收.png)
BONE
OAAI
BONEIF3.6
OAAI分享收藏分享收藏A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapyNATURE MEDICINE
NATURE MEDICINEIF50
PREAI
分享收藏Selective inhibition of NF-κB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivoNATURE MEDICINE
NATURE MEDICINEIF50
PREAI
分享收藏
查看更多内容