Perchlorate and thyroid function

Handler, Stacy N.

doi:10.1016/j.coemr.2025.100589

2025-10-01

PRE

Handler, Stacy N.

Maria A. Luna Cuadros

Elizabeth N. Pearce *

DOI：10.1016/j.coemr.2025.100589

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摘要

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高氯酸盐是一种全球范围内存在的环境污染物。高氯酸盐通过抑制钠碘转运体（该转运体将碘运入甲状腺）来干扰甲状腺功能。高氯酸盐对甲状腺功能的影响在妊娠期间尤为令人关注。本综述聚焦于与高氯酸盐甲状腺效应相关的人类研究。最早的一些关于高氯酸盐与甲状腺功能的人类研究，通过随机对照试验和职业研究探讨了高剂量暴露。这些研究逐渐让位于关注环境暴露的流行病学和队列研究。这些研究的结果各不相同，但表明高水平的环保高氯酸盐暴露，尤其是在碘缺乏的情况下，可能会损害甲状腺功能和胎儿神经发育。监管工作的开展得到了生物学剂量依赖性反应模型的建立支持。理解这一文献体系对于制定旨在监管高氯酸盐暴露和保护社会中最弱势群体的政策至关重要。

Keyword:

LOW-DOSE PERCHLORATE

ENVIRONMENTAL PERCHLORATE

THIOCYANATE EXPOSURE

SYMPORTER NIS

PREGNANCY

IODIDE

期刊

Current Opinion in Endocrine and Metabolic Research

IF:

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被引数:

机构

Boston University

学者数:

1.2K

论文数: 492

被引数: 350

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