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Perchlorate and thyroid function
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DOI：10.1016/j.coemr.2025.100589.png)
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Abstract
En 中文
Perchlorate is an environmental contaminant found around the world. Perchlorate disrupts thyroid function by inhibiting the sodium iodide symporter, which transports iodide into the thyroid. The impact of perchlorate on thyroid function is of particular concern during gestation. This review focuses on human studies related to the thyroidal effects of perchlorate. Some of the earliest human studies of perchlorate and thyroid function studied high-dose exposure through randomized control trials and occupational studies. These gave way to epidemiologic and cohort studies focusing on environmental exposures. The results of these studies have been variable but suggest that high levels of environmental perchlorate exposure, particularly in the setting of iodine deficiency, may impair thyroid function and fetal neurological development. Regulatory efforts have been supported by the advent of biologically dose-dependent response models. Understanding this body of the literature is critical for developing policies aimed at regulating perchlorate exposures and protecting society's most vulnerable populations.
Keywords:
LOW-DOSE PERCHLORATE
ENVIRONMENTAL PERCHLORATE
THIOCYANATE EXPOSURE
SYMPORTER NIS
PREGNANCY
IODIDE
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