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Perfecting antigen prediction
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DOI：10.1084/jem.20220846.png)
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摘要
En 中文
Advances in genomics and precision measurement have continued to demonstrate the importance of the immune system across many disease types. At the heart of many emerging approaches to leverage these insights for precision immunotherapies is the computational antigen prediction problem. We propose a threefold approach to improving antigen predictions: further defining the geometry of the antigen landscape, incorporating the coupling of antigen recognition to other cellular processes, and diversifying the training sets used for models that predict immunogenicity.
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期刊
J
IF:
10.6
论文数:
2.4W
被引数:
6.2W
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Six-locus high resolution HLA haplotype frequencies derived from mixed-resolution DNA typing for the entire US donor registry.png)
HUMAN IMMUNOLOGYOAAI
HUMAN IMMUNOLOGYIF2.2
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