.png){kind=icon}
返回
Perfusion Quantification by Model-Free Arterial Spin Labeling Using Nonlinear Stochastic Regularization Deconvolution
.png){kind=icon}
OA
AI
DOI：10.1002/mrm.24587.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
PurposeQuantification of cerebral blood flow can be accomplished by model-free arterial spin labeling using the quantitative STAR labeling of arterial regions (QUASAR) sequence. The required deconvolution is normally based on block-circulant singular value decomposition (cSVD)/oscillation SVD (oSVD), an algorithm associated with nonphysiological residue functions and potential effects of arterial dispersion. The aim of this work was to amend this by implementing nonlinear stochastic regularization (NSR) deconvolution, previously used to retrieve realistic residue functions in dynamic susceptibility contrast MRI. MethodsTo characterize the residue function in model-free arterial spin labeling, and possibly to improve absolute cerebral blood flow quantification, NSR was applied to deconvolution of QUASAR data. For comparison, SVD-based deconvolution was also employed. Residue function characteristics and cerebral blood flow values from 10 volunteers were obtained. Simulations were performed to support the in vivo results. ResultsNSR was able to resolve realistic residue functions in contrast to the SVD-based methods. Mean cerebral blood flow estimates in gray matter were 36.6 2.6, 28.6 +/- 3.3, 40.9 +/- 3.6, and 42.9 +/- 3.9 mL/100 g/min for cSVD, oSVD, NSR, and NSR with correction for arterial dispersion, respectively. In simulations, the NSR-based perfusion estimates showed better accuracy than the SVD-based approaches. ConclusionPerfusion quantification by model-free arterial spin labeling is evidently dependent on the selected deconvolution method, and NSR is a feasible alternative to SVD-based methods. Magn Reson Med 70:1470-1480, 2013. (c) 2012 Wiley Periodicals, Inc.
Keyword:
arterial spin labeling
deconvolution
cerebral blood flow
期刊
IF:
3
论文数:
1.2W
被引数:
3.1W
机构
引用论文
.png){kind=icon}
查看更多内容