.png){kind=icon}
返回
Pericentriolar material structure and dynamics
.png){kind=icon}
OA
AI
DOI：10.1098/rstb.2013.0459.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
A centrosome consists of two barrel-shaped centrioles embedded in a matrix of proteins known as the pericentriolar material (PCM). The PCM serves as a platform for protein complexes that regulate organelle trafficking, protein degradation and spindle assembly. Perhaps most important for cell division, the PCM concentrates tubulin and serves as the primary organizing centre for microtubules in metazoan somatic cells. Thus, similar to other well-described organelles, such as the nucleus and mitochondria, the cell has compartmentalized a multitude of vital biochemical reactions in the PCM. However, unlike these other organelles, the PCM is not membrane bound, but rather a dynamic collection of protein complexes and nucleic acids that constitute the organelle's interior and determine its boundary. How is the complex biochemical machinery necessary for the myriad centrosome functions concentrated and maintained in the PCM? Recent advances in proteomics and RNAi screening have unveiled most of the key PCM components and hinted at their molecular interactions (table 1). Now we must understand how the interactions between these molecules contribute to the mesoscale organization and the assembly of the centrosome. Among outstanding questions are the intrinsic mechanisms that determine PCM shape and size, and how it functions as a biochemical reaction hub.
Keyword:
pericentriolar material
centrosome
organelle scaling
microtubule-organizing centre
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
4.7
论文数:
8.7K
被引数:
5.6W
机构
引用论文
Centrosome maturation and mitotic spindle assembly in C-elegans require SPD-5, a protein with multiple coiled-coil domains.png)
DEVELOPMENTAL CELL
OAAI
DEVELOPMENTAL CELLIF8.7
OAAI分享收藏Centrioles Regulate Centrosome Size by Controlling the Rate of Cnn Incorporation into the PCMCURRENT BIOLOGYOAAI
CURRENT BIOLOGYIF7.5
OAAI分享收藏
查看更多内容