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Perilesional neuromodulation replaces lost sensorimotor function in persons with spinal cord injury
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DOI：10.1038/s41551-026-01627-5.png)
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Abstract
En 中文
Spinal cord injury (SCI) results in permanent impairment of sensory, motor and autonomic function. Epidural electrical stimulation (EES) applied below the lesion can restore voluntary movement, autonomic function and locomotion following chronic SCI. However, impaired sensation below the SCI does not improve during the application of sublesional EES. Here we present first-in-human results demonstrating simultaneous lower extremity motor activation and somatosensory feedback in three participants with motor complete, chronic SCI enabled by perilesional EES. We determined motor- and sensory-specific EES parameters by leveraging modern deep learning methods and participant-directed control of stimulation. Supralesional EES evoked sensations were synchronized with leg movement, enabling participants to accurately report leg position. We then applied simultaneous supralesional and sublesional EES, enabling intentional control over leg movements and somatosensory feedback during functional tasks. Overall, we demonstrate a perilesional EES framework to modulate sensorimotor function that may improve quality of life in individuals with SCI. Neuromodulation via epidural electrical stimulation both below and above the lesion in three participants with complete spinal cord injury could enable respectively motor activation and sensory perception.
Keywords:
Biomedical engineering
Sensorimotor processing
Translational research
Biomedicine
general
Biomedical Engineering/Biotechnology
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26.6
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1.7K
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2.0W
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Cited Papers