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Peripheral B cell subsets
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DOI：10.1016/j.coi.2008.03.014.png)
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摘要
En 中文
Our understanding of the origins and the biological functions of different peripheral B cell subsets continues to evolve. Some understanding has been obtained regarding the synergy between BCR-derived signals and other receptors and signaling pathways that drive the development of follicular, marginal zone, and B-1 B cells, but this remains a complex and poorly understood issue. More recent information regarding the origins of B-1 and B-2 B cells, the ability of follicular B cells to mature both in the bone marrow and the spleen, the existence of a definable precursor for MZ B cells, and the ability of follicular B cells to occupy two distinct niches are all highlighted in this review.
Keyword:
TOLL-LIKE RECEPTORS
MARGINAL-ZONE
BONE-MARROW
INDEPENDENT RESPONSES
POSITIVE SELECTION
SURVIVAL SIGNALS
DENDRITIC CELLS
T-CELLS
LYMPHOCYTES
SPLEEN
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5.8
论文数:
3.4K
被引数:
9.5K
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B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals脾脏中的b细胞发育以不连续的步骤进行，并由b细胞受体衍生信号的质量决定OAAI
OAAI分享收藏Functional heterogeneity of marginal zone B cells revealed by their ability to generate both early antibody-forming cells and germinal centers with hypermutation and memory in response to a T-dependent antigen边缘区b细胞的功能异质性通过其产生早期抗体形成细胞和具有高突变和记忆的生发中心的能力来揭示，以应对T依赖性抗原OAAI
OAAI分享收藏Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage developmentNotch2优先在成熟的b细胞中表达，对于边缘区B谱系的发育是必不可少的.png)
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