Perspective: Emerging challenges for a future ADNI

doi:10.1002/alz.14534

2025-02-26

Zaven S. Khachaturian

María C. Carrillo

Ara S. Khachaturian

DOI：10.1002/alz.14534

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摘要

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在过去的二十年中，阿尔茨海默症神经影像学计划（ADNI）显著提升了我们对阿尔茨海默症及相关痴呆症的检测与诊断方面的理解、技术及方法。本观点提出，应重新定位ADNI以应对新兴的研究与医疗挑战。其重点将转向认知障碍的早期检测、新干预措施的发现、非药物治疗方案的评价、公共卫生方法的采纳以及纳入多元化的国际队列。该新模型的关键要素包括强调血管-代谢因素、利用生物标志物以及增强计算能力。通过重新构想ADNI的使命与框架，该计划可能更好地应对痴呆症研究不断演变的复杂性，并通过更全面、跨学科的方法改善患者预后。

Keyword:

aging

Alzheimer's Association

Alzheimer's disease

Alzheimer's Disease Neuroimaging Initiative (ADNI)

biomarker

dementia

diagnosis

National Institute on Aging (NIA)

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Alzheimer and Dementia

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