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PGAM1 rheostat in glycolysis and autophagy

delete2026-08-07
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Kay F. Macleod *
DOI：10.1038/s41556-026-02033-4delete
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Abstract

Abstract

En 中文
How tumour cells rewire metabolic processes in response to changing nutrient availability in the tumour microenvironment is complex. Here, Zhang et al. define a role for PGAM1 in promoting autophagy in response to nutrient deprivation that competes with its catalytic function in glycolysis, which may explain selection for PGAM1 overexpression in cancer.

Journal

Nature Cell Biology cover
Nature Cell Biology
IF:
19.1
Papers:
6.1K
Citations:
4.8W

Organization

U
university of chicago
Scholars:
4.4W
Papers: 3.7W
Citations: 80
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