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Phase correlation spectroscopy: a technique to quantify microparticle diffusion
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DOI：10.1016/j.optlaseng.2026.109606.png)
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Abstract
En 中文
• Introduces a label-free Phase Correlation Spectroscopy (PCS) technique inspired by fluorescence correlation spectroscopy (FCS). • Utilizes time-resolved phase fluctuations from quantitative phase maps analogo08us to fluorescence intensity fluctuations in FCS. • Determines diffusion coefficients of micron-sized polystyrene microspheres. • Hydrodynamic radius estimated from PCS-derived diffusion coefficients matches the actual microsphere dimensions, confirming method accuracy. • Results follow Fick’s second law for concentration-dependent diffusion. • Demonstrates a non-invasive, label-free alternative to conventional FCS for diffusion analysis.
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