Phylospect: a spectral operator framework for detecting episodic selection in codon evolution

M. Manjunath

doi:10.1016/j.ympev.2026.108653

Phylospect: a spectral operator framework for detecting episodic selection in codon evolution

2026-06-01

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M

M. Manjunath *

V

V.S. Raviraj

C

C.S. Damini

V

V. Shakunthala

DOI：10.1016/j.ympev.2026.108653

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• PHYLOSPECT detects branch-specific positive selection without likelihood optimisation. • Calibrated false positive rate (FPR = 0.058) under neutral GY94 simulation. • 3.3-fold lower FPR than PAML under multinucleotide mutation contamination. • Five- to ten-fold faster per branch than PAML branch-site Model A. • Complementary to PAML: detects branch-coherent distributed selection.

Phylospect: a spectral operator framework for detecting episodic selection in codon evolution

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