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Phytopathogens Reprogram Host Alternative mRNA Splicing
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DOI：10.1146/annurev-phyto-121423-041908.png)
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Alternative splicing (AS) is an evolutionarily conserved cellular process in eukaryotes in which multiple messenger RNA (mRNA) transcripts are produced from a single gene. The concept that AS adds to transcriptome complexity and proteome diversity introduces a new perspective for under-standing how phytopathogen-induced alterations in host AS cause diseases. Recently, it has been recognized that AS represents an integral component of the plant immune system during parasitic, commensalistic, and symbiotic interactions. Here, I provide an overview of recent progress detailing the reprogramming of plant AS by phytopathogens and the functional implications on disease phenotypes. Additionally, I discuss the vital function of AS of immune receptors in regulating plant immunity and how phytopathogens use effector proteins to target key components of the splicingmachinery and exploit alternatively spliced variants of immune regulators tonegate defense responses. Finally, the functional association between AS andnonsense-mediated mRNA decay in the context of plant-pathogen interfaceis recapitulated.
Keyword:
alternative splicing
plant spliceosome
splicing factors
effector proteins
immune receptors
plant immune system
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11.9
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1.1K
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