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Plasma Proteomic Signatures of Left Atrial Dysfunction and Cerebral Small Vessel Disease
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DOI：10.1016/j.jacbts.2026.101622.png)
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Abstract
En 中文
• The heart-brain connection is underpinned by CV and inflammatory signatures. • 8 biomarkers completely mediated associations between LA strain and CSVD. • TNFRSF11A and IGFBP-4 displayed greatest connectivity to circulating biomarkers. • Future studies are needed to elucidate pathological processes linking AtCM and CSVD.
Keywords:
biomarkers
cerebral microinfarcts
cerebral small vessel disease
left atrial strain
proteomics
white matter hyperintensity volume
AF
atrial fibrillation
AtCM
atrial cardiomyopathy
CMB
cerebral microbleed
CMI
cerebral microinfarct
CSVD
cerebral small vessel disease
CVD
cardiovascular disease
IGFBP
insulin-like growth factor binding protein
LA
left atrial
LAScd
left atrial conduit strain
LASct
left atrial contractile strain
LASr
left atrial reservoir strain
LAVI
left atrial volume indexed by body surface area
LV
left ventricular
MRI
magnetic resonance imaging
OPG
osteoprotegerin
RANK
receptor activator of nuclear factor kappa-β ligand
TNFRSF
tumor necrosis factor receptor superfamily member
TTE
transthoracic echocardiography
WMHv
white matter hyperintensity volume
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