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Platelets as localized conduits of TGF-β1 in the tumor microenvironment: implications for cancer progression and therapy
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DOI：10.1007/s13577-026-01430-z.png)
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Abstract
En 中文
Platelets are major circulating reservoirs of transforming growth factor-β1 (TGF-β1). After tumor-associated activation, they release latent TGF-β1 from α-granules or present it at the platelet surface through glycoprotein A repetitions predominant. The latent complex is then activated by integrins, proteases, mechanical forces, and local physicochemical conditions. Direct platelet-specific evidence supports roles for platelet-derived TGF-β1 in established tumor growth, epithelial–mesenchymal transition, immune suppression, and metastasis. Platelet-associated studies also suggest effects on stromal remodeling, circulating tumor cell adaptation, endothelial dysfunction, and pre-metastatic niche formation. However, the platelet origin of TGF-β1 remains unresolved in many settings. This review distinguishes platelet-specific evidence from platelet-associated findings and source-independent mechanistic extrapolations. It also examines whether the stage-dependent paradox of TGF-β signaling applies to platelet-derived TGF-β1. The current evidence mainly supports a tumor-promoting role in established and metastatic disease, whereas its role in tumor initiation remains unclear. We further compare systemic therapies with platelet-directed, platelet-guided, and other targeted TGF-β interventions.
Keywords:
Platelets
TGF-β1
Tumor microenvironment
Metastasis
Targeted therapy
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3.1
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1.5K
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2.7K
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