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Pleiotrophin regulates presynaptic assembly and function through heparan sulfate-dependent binding to neurexin1
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DOI：10.1016/j.celrep.2026.117827.png)
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Abstract
En 中文
• Pleiotrophin forms a complex with HS-neurexin1 in the brain • HS and neurexins are required for pleiotrophin’s presynaptic activity • Pleiotrophin promotes presynaptic assembly and function in the hippocampus • Loss of pleiotrophin impairs contextual fear discrimination
Keywords:
presynaptic assembly
extracellular glycan
synaptic organizer
proteoglycan
extracellular matrix
CP: neuroscience
CP: molecular biology
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