.png){kind=icon}
返回
.png){kind=icon}
.png){kind=icon}
摘要
En 中文
In many emerging new areas of research, for example in -omics sciences, complex data sets are generated implementing well-designed experiments with the aim to study the effects of factors on responses measured by high-through analytical platforms. The data sets are multivariate in their nature and require suitable data analysis techniques to be investigated. Partial Least Squares (PLS) regression has been developed and successfully applied to solve multivariate regression problems where data are correlated, redundant and noisy, but it is not able to take explicitly into account the experimental design used to generate the data. In this study, we adapt PLS to model data generated by crossed factorial designs. A new method based on constrained PLS2 regression and a type III sums of squares-like approach based on PLS2 are developed to treat orthogonal and non-orthogonal designs, respectively. Post-transformation and Procrustes analysis are applied to discover the 'latent' structure useful to investigate the relationships between factors and responses. The mathematical properties of the data decomposition, the inference process to assess the reliability of the model and some basic tools for model interpretation are presented and discussed. One simulated and two experimental data sets, one generated implementing an orthogonal design and one obtained by a non-orthogonal design, are investigated to show how the methodology works in practice.
Keyword:
PLS regression
Designed experiments
Latent variables
期刊
IF:
3.8
论文数:
4.6K
被引数:
1.3W
机构
引用论文
Characterisation of volatile profile and sensory analysis of fresh-cut Radicchio di Chioggia stored in air or modified atmosphere.png)
FOOD CHEMISTRY.png)
FOOD CHEMISTRYIF9.8
PREAI
.png){kind=icon}
分享.png){kind=icon}
收藏A Hybrid Agent-based Design Methodology for Dynamic Cross-layer Reliability in Heterogeneous Embedded Systems异构嵌入式系统中基于混合代理的动态跨层可靠性设计方法
PREAI
分享收藏Results of a Phase 2, Randomized, Double-Blind Study of Sorafenib Versus Placebo in Combination with Intensive Chemotherapy in Previously Untreated Patients with FLT3-ITD Acute Myeloid Leukemia (ALLG AMLM16)Blood
OAAI
BloodIF0
OAAI分享收藏分享收藏
查看更多内容