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Polarimetric total internal reflection biosensing
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DOI：10.1364/OE.19.007410.png)
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In this paper, a concept of polarimetric total internal reflection (TIR) biosensor based on the method of temporal phase modulation is presented. Measurements of the phase difference between s- and p-polarized light combined with their amplitudes allow simultaneous detection of the bulk refractive index and thickness of the surface biofilms. Obtained experimental sensitivity is better than 10(-5) in terms of refractive index unit and 0.5 nm in biolayer thickness. Relatively simple technological implementation of the TIR sensors on the base of inexpensive and transparent substrates opens a number of novel applications in biosensing and microscopy. (C)2011 Optical Society of America
期刊
IF:
3.3
论文数:
6.1W
被引数:
14.3W
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