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Polyamine metabolic reprogramming in ependymal cells promotes endogenous repair after spinal cord injury
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DOI：10.1016/j.nbd.2026.107537.png)
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Abstract
En 中文
• SCI triggers polyamine metabolic reprogramming to activate ependymal cells. • Polyamine metabolism supports ependymal stemness and proliferation. • PLP treatment enhances polyamine metabolism in ependymal cells after SCI. • PLP treatment promotes ependymal proliferation and locomotor recovery after SCI.
Keywords:
Polyamine metabolic reprogramming
Ependymal cells
Spinal cord injury
Ornithine decarboxylase 1
Pyridoxal 5′-phosphate
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