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Polycationic Glycosides
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DOI：10.3390/molecules16021508.png)
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摘要
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Cationic lipids have long been known to serve as antibacterial and antifungal agents. Prior efforts with attachment of cationic lipids to carbohydrate-based surfaces have suggested the possibility that carbohydrate-attached cationic lipids might serve as antibacterial and antifungal pharmaceutical agents. Toward the understanding of this possibility, we have synthesized several series of cationic lipids attached to a variety of glycosides with the intent of generating antimicrobial agents that would meet the requirement for serving as a pharmaceutical agent, specifically that the agent be effective at a very low concentration as well as being biodegradable within the organism being treated. The initial results of our approach to this goal are presented.
Keyword:
polycationic lipid
glycoside
cyclodextrin
starch
1,4-diazabicyclo[2.2.2]-octane
antibacterial
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4.6
论文数:
6.5W
被引数:
23.7W
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