Polyreactive IgM: a trigger for aHUS

doi:10.1182/blood.2024026964

2024-12-12

Lubka T. Roumenina

Jordan D. Dimitrov

DOI：10.1182/blood.2024026964

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摘要

En 中文

在本期《Blood》杂志中，Cole等人¹采用一种新型的细胞生物传感器模型，揭示出多反应性免疫球蛋白M（IgM）诱导的经典补体通路激活可能是补体介导或非典型溶血尿毒症综合征（CM-HUS/aHUS）患者中启动疾病的缺失触发因素。经典补体蛋白曾被认为在CM-HUS的病理过程中是无关紧要的旁观者。然而，Cole等人的研究揭示，它们实际上更像是罗伯特·路易斯·史蒂文森笔下著名的转化角色Dr. Jekyll。

Keyword:

HEME

期刊

Blood

IF:

23.1

论文数:

5.5K

被引数:

16.6W

机构

Sorbonne Universite

学者数:

6.2W

论文数: 4.5W

被引数: 605

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