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Polystyrene nanoplastics induce fetal growth restriction via a novel NMNAT3 depletion cascade disrupting placental mitochondrial energetics and activating ferritinophagic ferroptosis
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DOI：10.1016/j.freeradbiomed.2026.08.010.png)
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Abstract
En 中文
• PS-NPs exposure impairs placental nicotinamide metabolism and mitochondrial energetics. • PS-NPs triggers NMNAT3 downregulation, NAD+ depletion, and ferritinophagy-driven ferroptosis. • NMNAT3 overexpression rescued PS-NPs-induced defects by inhibiting ferritinophagy-mediated ferroptosis. • NAM supplementation restores iron homeostasis, suppresses ferroptosis, and rescues adverse pregnancy outcomes.
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8.2
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2.1W
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5.4W
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