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Potassium Hexamethyldisilazide (KHMDS): Solvent-Dependent Solution Structures
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DOI：10.1021/jacs.4c03418.png)
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Solution structures of potassium hexamethyldisilazide [KHMDS] and labeled [N-15]KHMDS were examined using a number of analytical methods including 29Si NMR spectroscopy and density functional theory computations. A combination of N-15-Si-29 couplings, Si-29 chemical shifts, and the method of continuous variations reveals dimers, monomers, and ion pairs. Weakly coordinating monofunctional ligands such as toluene, N,N-dimethylethylamine, and Et3N afford exclusively dimers. 1,3-Dioxolane, THF, dimethoxyethane, hexamethylphosphoramide, and diglyme provide dimers at low ligand concentrations and monomers at high ligand concentrations. N,N,N ',N'-Tetramethylethylenediamine and N,N,N ',N'-tetramethylcyclohexanediamine provide exclusively dimers at all ligand concentrations at ambient temperatures and significant monomer at -80 degrees C. Studies of 12-crown-4 ran into technical problems. Equimolar 15-crown-5 forms a dimer, whereas excess 15-crown-5 affords a putative ion pair. Whereas equimolar 18-crown-6 also affords a dimer, an excess provides a monomer rather than a solvent-separated ion pair. [2.2.2]cryptand affords what is believed to be a contact-ion-paired cryptate. Solvation was probed using largely density functional theory (DFT) computations. Thermally corrected energies are consistent with lower aggregates and higher solvates at low temperatures, but the magnitudes of the computed temperature dependencies were substantially larger than the experimentally derived data.
Keyword:
C-H BOND
LITHIUM DIISOPROPYLAMIDE
ASYMMETRIC-SYNTHESIS
HIGHLY EFFICIENT
AGGREGATION
COMPLEXES
KINETICS
LIGAND
AMIDE
BASE
期刊
IF:
15.6
论文数:
20.0W
被引数:
60.2W
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