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Potential G-quadruplexes in the human long non-coding transcriptome
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DOI：10.4161/rna.9.1.18047.png)
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DNA G-quadruplexes are known as modulators of transcription. More recently G-quadruplexes, located in the untranslated regions of the mRNA of protein coding genes, have been described to negatively regulate gene expression at the post transcriptional/translational levels. Here we describe the possibility of the existence of G-quadruplexes in non-coding RNA (ncRNA) and discuss their potential biological roles. Using an in house prediction tool (Quadfinder) we observe a significant occurrence and distribution of G-quadruplexes in ncRNA of various sizes. We also observe that most of non-coding RNAs harboring these potential quadruplex motifs peak at the sizes ranging from 200-300 bases. More importantly we report enrichment for single and dinucleotide loops indicating a degree of high stability of these G-quadruplexes and their potential functions in vivo. Subsequent in vitro analyses of a subset of these sequences were performed which support our predictions.
Keyword:
RNA G-QUADRUPLEX
REPRESSES TRANSLATION
LOOP SIZE
DNA
SEQUENCE
STABILITY
MOTIFS
5-UTR
PROMOTER
APTAMER
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