.png){kind=icon}
返回
Precision insect control using programmable modular phage therapy platforms
.png){kind=icon}
PRE
AI
DOI：10.1016/j.tibtech.2025.12.005.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Spodoptera frugiperda, a major global pest, is resistant to several chemical insecticides via gut symbiont detoxification metabolism. This reduces the effectiveness of traditional control and increases insecticide residues and ecological risks, thereby threatening sustainable agriculture. Phage SP-1 (a newly isolated phage strain deposited at the China Center for Type Culture Collection (CCTCC) under accession number CCTCC M 20241620) targets and lyses the symbiont Enterococcus casseliflavus that mediates detoxification metabolism of insecticides, thereby restoring sensitivity to chlorantraniliprole. Zein-based nano-insecticide co-encapsulates SP-1 and chlorantraniliprole, withstands 60°C heat and UV. Compared with free chlorantraniliprole, the nano-insecticide improves Spodoptera frugiperda control by 17%, reduces soil residues by 82.4%, and is safe for the environmental microbial community and maize. The Modular Phage-based Symbiont Targeting platform enables flexible component swapping, offering a sustainable solution for resistant pests. The Modular Phage-based Symbiont Targeting system targets gut symbionts of Spodoptera frugiperda, rapidly reversing insecticide resistance. It reduces chemical pesticide use and residue while increasing control efficacy, offering a precise, adaptable, and eco-friendly solution for sustainable management of resistant agricultural pests.
期刊
IF:
14.9
论文数:
3.8K
被引数:
2.0W
机构
引用论文
Large-Scale Monitoring of the Frequency of Ryanodine Receptor Target-Site Mutations Conferring Diamide Resistance in Brazilian Field Populations of Fall Armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae).png)
Insects
OAAI
InsectsIF0
OAAI分享收藏Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammationCell
OAAI
CellIF0
OAAI分享收藏Antibiotics increased host insecticide susceptibility via collapsed bacterial symbionts reducing detoxification metabolism in the brown planthopper, Nilaparvata lugens抗生素通过塌陷的细菌共生体减少褐飞虱的解毒代谢来增加宿主杀虫剂的敏感性，Nilaparvata lugens
PREAI
分享收藏
查看更多内容