.png){kind=icon}
返回
Predicting concentration changes via discrete receptor sampling
.png){kind=icon}
OA
AI
DOI：10.1103/PhysRevResearch.6.033049.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
To successfully navigate chemical gradients, microorganisms need to predict how the ligand concentration changes in space. Due to their limited size, they do not take a spatial derivative over their body length but rather a temporal derivative, comparing the current signal with that in the recent past over the so-called adaptation time. This strategy is pervasive in biology, but it remains unclear what determines the accuracy of such measurements. Using a generalized version of the previously established sampling framework, we investigate how resource limitations and the statistics of the input signal set the optimal design of a well-characterized network that measures temporal concentration changes: the Escherichia coli chemotaxis network. Our results show how an optimal adaptation time arises from the trade-off between the sampling error, caused by the stochastic nature of the network, and the dynamical error, caused by uninformative fluctuations in the input. A larger resource availability reduces the sampling error, which allows for a smaller adaptation time, thereby simultaneously decreasing the dynamical error. Similarly, we find that the optimal adaptation time scales inversely with the gradient steepness, because steeper gradients lift the signal above the noise and reduce the sampling error. These findings shed light on the principles that govern the optimal design of the E. coli chemotaxis network specifically, and any system measuring temporal changes more broadly.
Keyword:
ESCHERICHIA-COLI
BACTERIAL CHEMOTAXIS
PERFECT ADAPTATION
SENSITIVITY
SYSTEMS
MODEL
期刊
IF:
4.2
论文数:
7.6K
被引数:
2.7W
机构
引用论文
Computerized analysis of chemotaxis at different stages of bacterial growth.png)
BIOPHYSICAL JOURNAL
OAAI
BIOPHYSICAL JOURNALIF3.1
OAAI分享收藏Bacterial chemoreceptor arrays are hexagonally packed trimers of receptor dimers networked by rings of kinase and coupling proteins细菌化学感受器阵列是由激酶和偶联蛋白环联网的受体二聚体的六角形堆积的三聚体OAAI
OAAI分享收藏分享收藏
查看更多内容