Primary Ovarian Insufficiency

Megan McCracken

doi:10.1016/j.bpobgyn.2025.102685

2025-12-02

PRE

Megan McCracken *

Nichole Tyson

DOI：10.1016/j.bpobgyn.2025.102685

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• 患有稀发月经、原发性闭经或继发性闭经的患者应进行所有潜在原因的检查，包括POI。 • POI定义为在40岁以下出现月经不规律，且促卵泡激素（FSH）两次检测结果处于“围绝经期范围”（25-40 IU/L或更高），两次检测间隔4周。 • 一旦确诊为POI，患者应进行以下必要检查：核型分析、FMR1基因前突变、21-OH Ab、抗肾上腺抗体、抗甲状腺球蛋白抗体、抗TPO抗体、乳糜泻筛查以及HbA1c检测。 • 对于伴有子宫的POI患者，激素替代治疗（HRT）包括雌激素和孕激素。首选经皮雌激素，但需根据具体情况选择最适合且依从性最佳的方案。 • 性活跃且不希望怀孕的POI患者需要可靠的避孕措施。未采取避孕措施的患者应建议补充叶酸（每日400～800 mcg），以降低意外怀孕时神经管缺陷的风险。

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Best Practice and Research Clinical Obstetrics and Gynaecology

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4.1

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2.0K

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6.2K

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Stanford University School of Medicine

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2.3K

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