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Programmed translational bypassing elements in mitochondria: structure, mobility, and evolutionary origin
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DOI：10.1016/j.tig.2015.02.010.png)
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Programmed translational bypassing enables ribosomes to 'ignore' a precise mRNA interval of several dozen nucleotides. Well-characterized bypassed sequences include hop and byp elements, present in bacteriophage T4 and mitochondria of the yeast Magnuslomyces capitatus, respectively. The bypassing mechanism of byps is probably similar to that of hop, yet the former appears more effective and less constrained as to sequence context. Furthermore, both elements are mobile but hop moves as part of a cassette including a homing endonuclease, whereas byps seem to spread like miniature DNA transposable elements known as GC clusters. Here, we argue that hop and byps arose independently by convergent evolution, and that byps evolved in magnusiomycete mitochondria due to (as yet unknown) alterations of the mitochondrial translation machinery.
Keyword:
byps
hop
GC clusters
DNA transposons
homing endonucleases
bacteriophage T4
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Secondary structure of bacteriophage T4 gene 60 mRNA: Implications for translational bypassing.png)
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OAAI分享收藏High-efficiency translational bypassing of non-coding nucleotides specified by mRNA structure and nascent peptideNATURE COMMUNICATIONSOAAI
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