.png){kind=icon}
返回
Prometaphase
.png){kind=icon}
OA
AI
DOI：10.1016/j.semcdb.2021.03.008.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
The establishment of a metaphase plate in which all chromosomes are attached to mitotic spindle microtubules and aligned at the cell equator is required for faithful chromosome segregation in metazoans. The achievement of this configuration relies on the precise coordination between several concurrent mechanisms that start upon nuclear envelope breakdown, mediate chromosome capture at their kinetochores during mitotic spindle assembly and culminate with the congression of all chromosomes to the spindle equator. This period is called 'prometaphase'. Because the nature of chromosome capture by mitotic spindle microtubules is error prone, the cell is provided of error correction mechanisms that sense and correct most erroneous kinetochore-microtubule attachments before committing to separate sister chromatids in anaphase. In this review, aimed for newcomers in the field, more than providing an exhaustive mechanistic coverage of each and every concurrent mechanism taking place during prometaphase, we provide an integrative overview of these processes that ultimately promote the subsequent faithful segregation of chromosomes during mitosis.
Keyword:
Prometaphase
Mitosis
Kinetochore
Mitotic spindle
Microtubule
Chromoso m e congression
Error correction
Tubulin code
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
6
论文数:
3.8K
被引数:
1.6W
机构
暂无机构信息
引用论文
Discrimination of the V600E Mutation in BRAF by Rolling Circle Amplification and Förster Resonance Energy Transfer.png)
ACS Sensors
ACS SensorsIF0
PREAI
分享收藏分享收藏HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochoreHJURP是一种CENP-染色质组装因子，足以形成功能性的从头kinetochoreOAAI
OAAI分享收藏
查看更多内容