PROTAC Technology: Opportunities and Challenges

Hongying Gao

doi:10.1021/acsmedchemlett.9b00597

2020-03-12

221

DOI：10.1021/acsmedchemlett.9b00597

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摘要

En 中文

PROTACs-induced targeted protein degradation has emerged as a novel therapeutic strategy in drug development and attracted the favor of academic institutions, large pharmaceutical enterprises (e.g., AstraZeneca, Bayer, Novartis, Amgen, Pfizer, GlaxoSmithKline, Merck, and Boehringer Ingelheim, etc.), and biotechnology companies. PROTACs opened a new chapter for novel drug development. However, any new technology will face many new problems and challenges. Perspectives on the potential opportunities and challenges of PROTACs will contribute to the research and development of new protein degradation drugs and degrader tools.

Keyword:

Proteolysis targeting chimeras

drug resistance

nonenzymatic function

undruggable target

reversible protein chemical knockdown

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期刊

ACS Medicinal Chemistry Letters

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论文数:

4.4K

被引数:

10.0K

机构

tsinghua university

学者数:

11.9W

论文数: 10.0W

被引数: 137

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