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Protein-protein docking benchmark version 3.0
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DOI：10.1002/prot.22106.png)
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We present version 3.0 of our publicly available protein-protein docking benchmark. This update includes 40 new test cases, representing a 48% increase from Benchmark 2.0. For all of the new cases, the crystal structures of both binding partners are available. As with Benchmark 2.0, Structural Classification of Proteins (Murzin et al, J Mol Biol 1995;247:536-540) was used to remove redundant test cases. The 124 unbound-unbound test cases in Benchmark 3.0 are classified into 88 rigid-body cases, 19 medium-difficulty cases, and 17 difficult cases, based on the degree of conformational change at the interface upon complex formation. In addition to providing the community with more test cases for evaluating docking methods, the expansion of Benchmark 3.0 will facilitate the development of new algorithms that require a large number of training examples. Benchmark 3.0 is available to the public at http://zlab.bu.edu/benchmark.
Keyword:
protein-protein docking
protein complexes
protein-protein interactions
complex structure
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2.8
论文数:
6.6K
被引数:
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A novel empirical free energy function that explains and predicts protein-protein binding affinities一种新颖的经验自由能函数，可以解释和预测蛋白质-蛋白质结合亲和力
PREAI
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