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Protein structural classification based on pseudo amino acid composition using SVM classifier

delete2013-01-01
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Zbigniew Krajewski *
E
Ewaryst Tkacz
DOI:10.1016/j.bbe.2013.03.002delete
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摘要

摘要

En 中文
This paper deals with a structural classification by the aid of support vector machine (SVM) classifier. Amino acid composition (AAC) and pseudo amino acid composition (PseAA) features were applied with different variants. Additionally the feature reflecting the length of protein chain was taken into consideration. The SVM classifier was compared to minimal-length classifiers with respect to the AAC features. The best model of SVM classifier was chosen using grid method on the basis of cross-validation (CV) as criterion. The best model of SVM classifier is evaluated with respect to proper evaluation rates. The SCOP database and the ASTRAL tool were a source of non-homologous data to avoid the redundancy and to ensure a maximal amount of available data. (C) 2013 Published by Elsevier Urban & Partner Sp. z o.o. on behalf of Nalecz Institute of Biocybemetics and Biomedical Engineering.
Keyword:
Pseudo amino acid composition
Support vector machine
Minimal-distance methods
Protein structural class
SCOP database
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期刊

Biocybernetics and Biomedical Engineering 封面图
Biocybernetics and Biomedical Engineering
IF:
6.6
论文数:
944
被引数:
3.3K

机构

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Silesian University of Technology
学者数:
6.2K
论文数: 6.2K
被引数: 5.9K
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