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Proteomic Profiling Reveals Region-Specific Neuroimmune and Apoptotic Signatures Induced by Bothrops jararaca Venom Toxins in the Murine Brain
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DOI：10.1016/j.biochi.2026.05.001.png)
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Abstract
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• Venom and antivenom modulate cortex and brainstem proteomes over time. • Modulated proteins relate to apoptosis, vasculogenesis, and inflammation. • Exclusive proteins indicate intense protein processing in envenomed brain tissues. • Antivenom mitigates venom effects in brain regions in time-dependent way. • Findings clarify CNS implications in systemic Bothrops jararaca envenomation.
Keywords:
Bothrops jararaca
envenomation
label-free proteomics
LC-MS/MS
mass spectrometry
central nervous system
neuroinflammation
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