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Protocadherin 10, a member of cadherin superfamily, increases stress-susceptibility in chronic unpredictable stress-treated rats
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DOI：10.1016/j.pbb.2026.174158.png)
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Abstract
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• Stress-susceptible rats and stress-resilient rats were distinguished by sucrose preference test. Stress-susceptible rats exhibited downregulated neurotransmitter level and decreased presynaptic vesicle density compared to stress-resilient rats. • PCDH10, MANF, Septin 11, and UFD1 were downregulated in the prefrontal cortex but upregulated in the hippocampus of stress-susceptible rats, all of which are opposite in the stress-resilient rats. • Knockdown of PCDH10 in the hippocampus of rats produced a resilient phenotype, effectively ameliorating depression-like behaviors in rats exposed to chronic unpredictable stress. • Overexpression of PCDH10 in the hippocampal of rats did not directly induce depression-like behaviors but markedly increases susceptibility to stress, leading to exacerbated behavioral deficits after stress exposure.
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