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Pseudouridylation-mediated gene expression modulation
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DOI：10.1042/BCJ20230096.png)
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摘要
En 中文
RNA-guided pseudouridylation, a widespread post-transcriptional RNA modification, has recently gained recognition for its role in cellular processes such as pre-mRNA splicing and the modulation of premature termination codon (PTC) readthrough. This review provides insights into its mechanisms, functions, and potential therapeutic applications. It examines the mechanisms governing RNA-guided pseudouridylation, emphasizing the roles of guide RNAs and pseudouridine synthases in catalyzing uridine-to-pseudouridine conversion. A key focus is the impact of RNA-guided pseudouridylation of U2 small nuclear RNA on pre-mRNA splicing, encompassing its influence on branch site recognition and spliceosome assembly. Additionally, the review discusses the emerging role of RNA-guided pseudouridylation in regulating PTC readthrough, impacting translation termination and genetic disorders. Finally, it explores the therapeutic potential of pseudouridine modifications, offering insights into potential treatments for genetic diseases and cancer and the development of mRNA vaccine.
Keyword:
CODON READ-THROUGH
SMALL NUCLEAR RNAS
YEAST U2 SNRNA
NONSENSE MUTATION
DYSKERATOSIS-CONGENITA
STOP CODON
SACCHAROMYCES-CEREVISIAE
RIBOSOMAL-RNA
SUBSTRATE RNA
IN-VITRO
期刊
IF:
4.3
论文数:
1.5W
被引数:
3.8W
机构
引用论文
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