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Psoriasis

delete2026-07-29
delete0
PRE
AI
L
Lihi Eder *
L
Lourdes Perez-Chada
W
Wilson Liao
J
Joseph F. Merola
DOI：10.1016/s0140-6736(26)00349-1delete
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摘要

摘要

En 中文
银屑病是一种常见的、慢性的、免疫介导的皮肤疾病，影响全球超过4000万人。银屑病及其银屑病关节炎是更广泛的银屑病疾病谱的一部分，其皮肤和肌肉骨骼炎症表现由共享的遗传、环境和免疫机制驱动。皮肤银屑病呈现多种临床表型，包括慢性斑块型银屑病、点滴状、掌跖部、红皮病型和脓疱型。除皮肤表现外，银屑病还与显著的身心负担以及多种并发症相关，包括精神健康障碍和心-代谢性疾病。银屑病的主要风险因素包括基因多态性（最显著的是HLA-C*06:02）、肥胖以及环境因素，如创伤、感染和特定药物。对IL-23–IL-17炎症轴及相关免疫遗传通路关键作用的深入理解，重新定义了银屑病为一种复杂的免疫失调，并推动了高度有效的靶向生物制剂和小分子疗法的发展，这些疗法可调节细胞因子信号和细胞内通路，从而在皮肤和肌肉骨骼领域实现更优的疾病控制。

期刊

The Lancet 封面图
The Lancet
IF:
88.5
论文数:
5.4W
被引数:
34.8W

机构

U
university of california san francisco
学者数:
5.3W
论文数: 4.0W
被引数: 67
U
ut southwestern medical center and o'donnell school of public health
学者数:
2
论文数: 1
被引数: 0
H
harvard medical school
学者数:
5.9K
论文数: 2.6K
被引数: 2
W
women's college hospital
学者数:
79
论文数: 44
被引数: 0
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