.png){kind=icon}
.png){kind=icon}
Return
Psychedelics align brain activity with context
.png){kind=icon}
OA
AI
DOI：10.1038/s41586-026-10910-z.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Psychedelics can profoundly alter consciousness by reorganizing brain connectivity1,2, producing acute experiences that shape lasting psychological change3,4. Psychedelic dynamics are commonly described as desynchronized or entropically disordered5,6, yet the brain organization underlying self-dissolving and boundary-dissolving experiences that participants often report7, and how context shapes that organization8, remain unresolved. To address this, we acquired the largest single-site psychedelic neuroimaging dataset to date. Sixty-two adults underwent functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) during rest and naturalistic stimuli (meditation, music and movie), before and on the day of psilocybin administration (fMRI ~ 80 min post-dose; EEG ~ 150 min post-dose). Half ranked the experience among the most meaningful of their lives7. Here, using machine learning to represent the brain dynamics of each individual as low-dimensional trajectories, we show that psilocybin reorganizes brain activity into structured, context-sensitive patterns that co-vary with the quality of subjective experience, revealing a latent order missed by time-averaged measures. Networks that ordinarily segregate internal and external processing integrated, producing cohesive context-aligned trajectories in participants reporting the felt experience of being continuous with, rather than separate from, the environment, a state we refer to as embeddedness. The strength of this context alignment scaled with both the depth of self-dissolving and boundary-dissolving experience and the next-day mindset change. Our findings recast apparent disorder as latent organization aligned with context, linking neurobiology to subjective experience and behavioural change. The psychedelic psilocybin reorganizes brain activity into structured, context-aligned patterns that integrate internal and external processing, providing a neural basis for the felt continuity between self and world, elucidating how the psychedelic state translates into psychological change.
Journal
IF:
48.5
Papers:
1.8W
Citations:
96.5W
Organization
View more organizations