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Pulmonary embolism

delete2018-05-17
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PRE
AI
M
Menno V. Huisman *
S
Stefano Barco
S
Suzanne C. Cannegieter
G
Grégoire Le Gal
S
Stavros Konstantinides
P
Pieter H. Reitsma
M
Marc Rodger
A
Anton Vonk Noordegraaf
F
Frederikus A. Klok
DOI:10.1038/nrdp.2018.28delete
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摘要

摘要

En 中文
Pulmonary embolism (PE) is caused by emboli, which have originated from venous thrombi, travelling to and occluding the arteries of the lung. PE is the most dangerous form of venous thromboembolism, and undiagnosed or untreated PE can be fatal. Acute PE is associated with right ventricular dysfunction, which can lead to arrhythmia, haemodynamic collapse and shock. Furthermore, individuals who survive PE can develop post-PE syndrome, which is characterized by chronic thrombotic remains in the pulmonary arteries, persistent right ventricular dysfunction, decreased quality of life and/or chronic functional limitations. Several important improvements have been made in the diagnostic and therapeutic management of acute PE in recent years, such as the introduction of a simplified diagnostic algorithm for suspected PE as well as phase III trials demonstrating the value of direct oral anticoagulants in acute and extended treatment of venous thromboembolism. Future research should aim to address novel treatment options (for example, fibrinolysis enhancers) and improved methods for predicting long-term complications and defining optimal anticoagulant therapy parameters in individual patients, and to gain a greater understanding of post-PE syndrome.
Keyword:
QUALITY-OF-LIFE
DEEP-VEIN THROMBOSIS
PATIENTS ANTITHROMBOTIC THERAPY
ED AMERICAN-COLLEGE
RULE-OUT CRITERIA
FACTOR-V-LEIDEN
SYMPTOMATIC VENOUS THROMBOEMBOLISM
RIGHT-VENTRICULAR DYSFUNCTION
ORAL ANTICOAGULANTS
THROMBOLYTIC THERAPY
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期刊

N
Nature Reviews Disease Primers
IF:
60.6
论文数:
648
被引数:
3.8W

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L
leiden university - excl lumc
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3.5W
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被引数: 46
U
university hospital mainz
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703
论文数: 512
被引数: 2
D
Democritus University of Thrace
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4.8K
论文数: 3.7K
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L
Leiden University
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4.0W
论文数: 3.3W
被引数: 3.8W
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