.png){kind=icon}
返回
Pulse-width modulated temporal interference (PWM-TI) brain stimulation
.png){kind=icon}
OA
AI
DOI：10.1016/j.brs.2023.12.010.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Background: Electrical stimulation involving temporal interference of two different kHz frequency sinusoidal electric fields (temporal interference (TI)) enables non-invasive deep brain stimulation, by creating an electric field that is amplitude modulated at the slow difference frequency (within the neural range), at the target brain region. Objective: Here, we investigate temporal interference neural stimulation using square, rather than sinusoidal, electric fields that create an electric field that is pulse-width, but not amplitude, modulated at the difference frequency (pulse-width modulated temporal interference, (PWM-TI)). Methods/Results: We show, using ex-vivo single-cell recordings and in-vivo calcium imaging, that PWM-TI effectively stimulates neural activity at the difference frequency at a similar efficiency to traditional TI. We then demonstrate, using computational modelling, that the PWM stimulation waveform induces amplitudemodulated membrane potential depolarization due to the membrane's intrinsic low-pass filtering property. Conclusions: PWM-TI can effectively drive neural activity at the difference frequency. The PWM-TI mechanism involves converting an envelope amplitude-fixed PWM field to an amplitude-modulated membrane potential via the low-pass filtering of the passive neural membrane. Unveiling the biophysics underpinning the neural response to complex electric fields may facilitate the development of new brain stimulation strategies with improved precision and efficiency.
Keyword:
Non-invasive brain stimulation
Temporal interference
Deep brain stimulation
期刊
IF:
8.4
论文数:
3.2K
被引数:
1.2W
机构
引用论文
分享收藏分享收藏Resonance, oscillation and the intrinsic frequency preferences of neurons神经元的共振，振荡和固有频率偏好.png)
TRENDS IN NEUROSCIENCES
TRENDS IN NEUROSCIENCESIF15.1
PREAI
分享收藏
查看更多内容