Pure steady-state CEST

Johannes Hammacher

doi:10.1016/j.mri.2025.110506

2025-09-01

Johannes Hammacher *

Christoph Kolbitsch

Patrick Schünke

DOI：10.1016/j.mri.2025.110506

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摘要

En 中文

一种基于CEST饱和期间纵向磁化量发展及数据采集的底层物理模型的新型稳态CEST序列设计被提出，并在计算机模拟、体外和体内进行了验证。该设计确保在纯CEST稳态下实现一致的数据采集，与当代的顺序式和稳态CEST序列相比，在体外和体内均能获得更高的MTRasym评分和图像质量。目的：本研究旨在通过利用纯CEST稳态来增强CEST序列，以提供更高的CEST效应和更好的灵敏度。方法：设计了一种新型的CEST饱和/读出方案，在数值模拟中进行了测试，并随后在体外和体内进行了验证。结果：新型的Multi-2D Spiral纯稳态CEST序列显示出优越的灵敏度和效能。结论：将图像采集限制在纯CEST稳态下在初步的体外和体内实验中显示出有希望的结果。

Keyword:

CEST

Steady-state

Spirals

Interleave

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期刊

Journal of Magnetic Resonance Imaging

IF:

3.5

论文数:

9.9K

被引数:

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